Birth, life and death of nascent polypeptide chains
نویسندگان
چکیده
منابع مشابه
Birth, life and death of nascent polypeptide chains
The journey of nascent polypeptides from synthesis at the peptidyl transferase center of the ribosome ("birth") to full function ("maturity") involves multiple interactions, constraints, modifications and folding events. Each step of this journey impacts the ultimate expression level and functional capacity of the translated protein. It has become clear that the kinetics of protein translation ...
متن کاملViewing folding of nascent polypeptide chains from ribosomes.
Regulation of gene expression occurs at multiple stages and ultimately determines the protein levels in cells. The last decade has witnessed impressive progress in the development of approaches to measuring changes in cellular transcription and protein complement. However, techniques monitoring protein synthesis have lagged far behind. Current proteomic studies gauge the steady state levels of ...
متن کاملO-GlcNAc occurs cotranslationally to stabilize nascent polypeptide chains.
Nucleocytoplasmic glycosylation of proteins with O-linked N-acetylglucosamine residues (O-GlcNAc) is recognized as a conserved post-translational modification found in all metazoans. O-GlcNAc has been proposed to regulate diverse cellular processes. Impaired cellular O-GlcNAcylation has been found to lead to decreases in the levels of various proteins, which is one mechanism by which O-GlcNAc s...
متن کاملNascent polypeptide-associated complex protein prevents mistargeting of nascent chains to the endoplasmic reticulum.
We show that, after removal of the nascent polypeptide-associated complex (NAC) from ribosome-associated nascent chains, ribosomes synthesizing proteins lacking signal peptides are efficiently targeted to the endoplasmic reticulum (ER) membrane. After this mistargeting, translocation across the ER membrane occurs, albeit less efficiently than for a nascent secretory polypeptide, perhaps because...
متن کاملSpectral Computations for Birth and Death Chains
We consider the spectrum of birth and death chains on a n-path. An iterative scheme is proposed to compute any eigenvalue with exponential convergence rate independent of n. This allows one to determine the whole spectrum in order n elementary operations. Using the same idea, we also provide a lower bound on the spectral gap, which is of the correct order on some classes of examples.
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ژورنال
عنوان ژورنال: Biotechnology Journal
سال: 2011
ISSN: 1860-6768
DOI: 10.1002/biot.201000327